Journal article
Phytochemical Profiling Studies of Alkaloids and Coumarins from the Australian Plant Geijera parviflora Lindl. (Rutaceae) and Their Anthelmintic and Antimicrobial Assessment
D Dugan, RJ Bell, R Brkljača, C Rix, AC Taki, RB Gasser, S Urban
Metabolites | MDPI | Published : 2024
Abstract
Phytochemical profiling followed by antimicrobial and anthelmintic activity evaluation of the Australian plant Geijera parviflora, known for its customary use in Indigenous Australian ceremonies and bush medicine, was performed. In the present study, seven previously reported compounds were isolated including auraptene, 6′-dehydromarmin, geiparvarin, marmin acetonide, flindersine, and two flindersine derivatives from the bark and leaves, together with a new compound, chlorogeiparvarin, formed as an artefact during the isolation procedure and isolated as a mixture with geiparvarin. Chemical profiling allowed for a qualitative and quantitative comparison of the compounds in the leaves, bark, f..
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Awarded by RMIT University
Funding Acknowledgements
The MATNAP research group would like to thank curators Bronwyn Swartz (Royal Botanic Gardens Cranbourne, Victoria, Australia) and Andrea Dennis (Maranoa Botanical Gardens, Balwyn, Victoria, Australia) for identifying and collecting the plant specimens that were provided for this study. We gratefully acknowledge Stephen Grist and Lydon Alexandrou for technical support with HPLC and LC-MS instrumentation and Kyle Hearn for technical support with NMR instrumentation. Finally, we would like to thank CO-ADD (Community for Open Antimicrobial Drug Discovery) for performing antimicrobial screening of compounds purified in this study.